Πρόσφατες δημοσιεύσεις στο περιοδικό The Lancet HIV

HIV vaccine: better to start together?

With 37Β·9 million people infected by HIV worldwide, and 1Β·7 million people newly infected in 2018,1 development of a vaccine against HIV is of upmost importance to prevent HIV infection. Findings of the HIV vaccine trial RV1442 showed modest (31Β·2%) vaccine efficacy with a canarypox vector (ALVAC) expressing HIV genes as a prime followed by two booster immunisations with the ALVAC vector plus recombinant HIV gp120 envelope (Env) glycoprotein (AIDSVAX B/E). Correlates of reduced risk of infection were non-neutralising antibodies against the variable V1/V2 region of Env protein and antibodies mediating antibody-dependent cellular cytotoxicity.

Transition to third-line ART in resource-limited settings

In The Lancet HIV, Serge Eholie and colleagues1 present results of a prospective cohort study done in four west African countries with little access to genotypic antiretroviral resistance testing. They explored the usefulness of an intensive programme of enhanced adherence support in adults with treatment failure of protease inhibitor-based second-line antiretroviral therapy (ART), to distinguish individuals likely to have genotypic resistance and need third-line ART from those with treatment failure because of poor adherence.

Time to strengthen HIV treatment and prevention for youth

In The Lancet HIV, Mhairi Maskew and colleagues1 use data from a large national laboratory database in South Africa to examine trends in access to public sector HIV treatment programmes by children and adolescents aged 1–19 years between 2005 and 2016. The authors should be congratulated for highlighting important findings using national data in this often underexamined population, information that is needed to mount a national response. The authors report a ten times increase in the number of adolescents with viral load data, suggestive of antiretroviral therapy (ART) use, between 2005–08 and 2013–16.

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Στο, φιλοξενούμε αφιλοκερδώς το "Πρόγραμμα Συνεργασίας" Μονάδων Λοιμώξεων για την ανάπτυξη διαδικτυακής τράπεζας κλινικών παραμέτρων. Το Πρόγραμμα δημιουργήθηκε από έναν γιατρό ειδικό στην HIV λοίμωξη με τη συμμετοχή των Μονάδων: Περισσότερα

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