Lancet

Πρόσφατες δημοσιεύσεις στο περιοδικό The Lancet HIV

17 alpha-hydroxyprogesterone caproate, HIV, and preterm birth

Worldwide, preterm birth is the second leading cause of death in children younger than 5 years.1 The prevalence of preterm birth is significantly higher in low-income and middle-income countries than in high-income countries,1,2 and in sub-Saharan Africa (where maternal HIV infection substantially increases the risk of preterm birth and other adverse perinatal outcomes2) one in five children are born preterm.1–3 HIV infection is associated with both vaginal and systemic inflammation,4 as well as abnormal placental angiogenesis,5 which all contribute to spontaneous preterm birth.

Tackling cancer risk in adolescents and young adults with HIV

Although much has been written about the risk factors that lead to cancer in people with HIV, adolescents and young adults (AYAs; aged 15–24 years), with all their complex psychosocial comorbidities, are a uniquely vulnerable population.1 In The Lancet HIV, Yann Ruffieux and colleagues2 assessed a large cohort of AYAs living with HIV from South Africa; they describe the incident cancers in this group and the risk factors for developing those cancers. There can be no more appropriate setting because about 80% of the world's AYAs with HIV live in sub-Saharan Africa, of whom at least 20% are in South Africa.

[Correspondence] Incidence data do not count everyone

We welcome Risher and colleagues’1 Article on the age patterns of HIV incidence using cohorts from southern and eastern Africa. We note that the upper age limit of the data presented is 54 years, with an upper age limit of 49 years for some cohorts. According to the authors, this is because of β€œlimited serosurveillance in those younger than 15 years and older than 54 years”. However, the main finding of the paper is that incidence has shifted to older ages.

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