Πρόσφατες δημοσιεύσεις στο περιοδικό The Lancet HIV

Influenza vaccine in pregnant women with HIV: are we there?

In The Lancet HIV, Marta Nunes and colleagues report their clinical trial assessing three different approaches to influenza vaccination in pregnant women with HIV in South Africa.1 Recognising that the standard vaccine, while licensed, might not be the best approach, they compared the safety and immunogenicity of a double dose of a seasonal vaccine to a booster dose of the vaccine with the standard dose of the same influenza vaccine. Their reasons for choosing these different approaches was because immune responses to standard vaccination in this population are poor, with downstream concerns for risk for influenza disease in both mother and baby.

Circulating resistance to first-line HIV drug regimens

Pretreatment HIV drug resistance (PDR) is increasing in sub-Saharan Africa, driven by increasing resistance to non-nucleoside reverse transcriptase inhibitor (NNRTI) drugs.1 This has led WHO to recommend that countries with a population prevalence of NNRTIs resistance greater than 10% adopt alternative first-line regimens, or consider PDR testing to guide selection of antiretroviral therapy (ART).1,2 In response, many countries in sub-Saharan Africa are now rolling out dolutegravir-based first-line ART.

On-demand PrEP efficacy: forgiveness or timely dosing

Oral daily pre-exposure prophylaxis (PrEP) containing tenofovir disoproxil fumarate plus emtricitabine can be highly protective against HIV infection. However, its effectiveness is dependent on drug intake. In large randomised placebo-controlled trials,1,2 objective measures of adherence have closely predicted the extent of protection against HIV in the intention-to-treat population (figure). The proxy for adherence was the percentage of patients for whom tenofovir was detected in plasma in all studies, with the exception of the PROUD study that used the percentage of days covered by PrEP over 2 years of follow-up.

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Στο, φιλοξενούμε αφιλοκερδώς το "Πρόγραμμα Συνεργασίας" Μονάδων Λοιμώξεων για την ανάπτυξη διαδικτυακής τράπεζας κλινικών παραμέτρων. Το Πρόγραμμα δημιουργήθηκε από έναν γιατρό ειδικό στην HIV λοίμωξη με τη συμμετοχή των Μονάδων: Περισσότερα

% Αναπηρία και HIV

Νέος κανονισμός

Ενιαίος Πίνακας Προσδιορισμού Ποσοστού Αναπηρίας


@ Διαύγεια


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