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Lancet

Πρόσφατες δημοσιεύσεις στο περιοδικό The Lancet HIV

Potential for broadly neutralising antibodies as PrEP

Globally, an estimated 40 million people live with HIV. Although 30Β·7 million of the people living with HIV have access to antiretroviral therapy, there were still 1Β·3 million new infections in 2022.1 There is an urgent need to prevent HIV acquisition through effective prevention programmes, including pre-exposure prevention (PrEP) or, ideally, a prophylactic vaccine.

Improving quality of interpersonal care in HIV programmes

The response to the HIV epidemic has shifted from providing care primarily for individuals who are severely ill to a more inclusive approach aimed at expanding access to HIV services.1 Poor quality care, resulting from inefficiencies in clinic systems, staff shortages, and stigmatising or discriminatory behaviours from health-care workers,2–5 can negatively affect client engagement, whereas respect, dignity, empathy, compassion, and clear communication can improve engagement.3,6,7 Although differentiated service delivery models have addressed some structural barriers,8 interventional studies are needed to show how to improve the quality of interpersonal interactions between clients and health-care workers and whether this improvement affects HIV treatment outcomes.

Injectable antiretrovirals: real world or ideal world?

Following on the results of formal randomised clinical trials, real-world data can provide important insights into the safety and efficacy of a new drug regimen when it is used among a more diverse patient population and in a less controlled clinical setting. As Jongen and colleagues1 point out in The Lancet HIV, available real-world data for long-acting injectable cabotegravir and rilpivirine are largely limited to retrospective analyses with small sample sizes.1 The authors aim to address this issue using data from the well established ATHENA cohort, which includes comprehensive data for almost all people living with HIV receiving medical care in the Netherlands.

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