Lancet

Πρόσφατες δημοσιεύσεις στο περιοδικό The Lancet HIV

Another step towards closing the paediatric treatment gap

Expanding access to antiretroviral therapy (ART) and reducing new HIV acquisitions among women has led to a marked decline in vertical HIV transmission over the past decade. Nevertheless, in 2023 alone, an estimated 120β€ˆ000 children aged 0–14 years acquired HIV globally, with the vast majority living in Africa.1 Without treatment, over half of infants and young children with perinatally acquired HIV die before their second birthday.2 Early diagnosis and timely linkage to care are therefore essential to reducing morbidity and mortality.

Deworming of filariasis and reduction of HIVβ€ˆincidence

In sub-Saharan Africa, lymphatic filariasis and HIV infection are two major public health problems that often coexist.1 For several decades, scientists have been exploring the negative impact of helminth infections, including the filarial nematode Wucheria bancrofti, on HIV acquisition and pathogenesis.1–3 Immunological studies have tried to validate the anecdotal, but biologically plausible, theory that modulatory effects of helminths such as W bancrofti can affect HIV infection.3–5 However, some of these studies were inconclusive, and many were characterised by two common flaws, cross-sectional design1 or small sample size,3 weakening the strength of the evidence.

Modelling study shows staggering impact of HIV funding cuts

The global AIDS response has seen substantial reductions in HIV incidence and number of deaths.1 The greatest improvements have been recorded in sub-Saharan Africa, the region with the worst HIV burden. Many of the advances are attributed to international funding of national programmes within sub-Saharan Africa. International contributions were estimated to be 41% of total HIV expenditure in low-income and middle-income countries (LMICs) in 2023.1 Over the last 5–10 years there have been reported declines in HIV funding from both domestic contributions and non-US international funders.

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