Tue, 17 Apr 2018 00:00:00 GMT-05:00 - Muiru, Anthony N.; Bibangambah, Prossy; Hemphill, Linda; Sentongo, Ruth; Kim, June-Ho; Triant, Virginia A.; Bangsberg, David R.; Tsai, Alexander C.; Martin, Jeffrey N.; Haberer, Jessica E.; Boum, Yap II; Plutzky, Jorge; Hunt, Peter W.; Okello, Samson; Siedner, Mark J. Εισαγωγή:
The utility and validity of CVD risk scores are not well-studied in sub-Saharan Africa. We compared and correlated CVD risk scores with carotid intima media thickness (c-IMT) among HIV-infected and uninfected people in Uganda.
Μέθοδοι:
We first calculated CVD risk using the 1) Framingham laboratory-based score; 2) Framingham non-laboratory score (FRS-BMI); 3) Reynolds risk score; 4) American College of Cardiology and American Heart Association score; and 5) the Data-collection on Adverse Effects of Anti-HIV Drugs score. We then compared absolute risk scores and risk categories across each score using Pearson correlation, and kappa statistics, respectively. Finally, we fit linear regression models to estimate the strength of association between each risk score and c-IMT.
Αποτελέσματα:
Of 205 participants, half were female and median age was 49 years (IQR 46, 53). Median CD4 count was 430 cells/mm3 (IQR 334, 546), with median 7 years of ART exposure (IQR 6.4, 7.5). HIV-uninfected participants had a higher median systolic blood pressure (121 mmHg vs. 110 mmHg), prevalent current smoking (18% vs. 4%, p=0.001), higher median CVD risk scores (p<0.003), and greater c-IMT (0.68 vs. 0.63, p=0.003). Overall, FRS-BMI was highly correlated with other risk scores (all rho >0.80). In linear regression models, we found significant correlations between increasing CVD risk and higher c-IMT (p<0.01 in all models).
Συμπεράσματα:
In this cross-sectional study from Uganda, the FRS-BMI correlated well with standard risk scores and c-IMT. HIV-uninfected individuals had higher risk scores than HIV-infected individuals, and the difference appeared to be driven by modifiable factors.
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Correspondence: Anthony N Muiru, 533 Parnassus Avenue U404, Box 0532, San Francisco, CA 94143 Tel: 415 474 2172, Fax: 415 476 3381, Email: Anthony.muiru@ucsf.edu
* Current affiliation: Department of Medicine, Division of Nephrology, University of California San Francisco, San Francisco, California, USA.
^ Oregon Health Sciences University-Portland State University School of Public Health, Portland, Oregon, USA
The authors report no conflicts of interest related to this work.
Meetings: This abstract was presented at the 9th International Aids Society Conference on HIV Science. July 23-26, 2017, Paris France.
Funding: This work was supported by National Institute of Health (NIH) [K23 MH099916, R21 HL124712, R24 AG 044235, R01 MH054907, and K43 TW010715], Friends of a Healthy Uganda, the Harvard Center for AIDS Research [5P30AI060354-12], and Massachusetts General Hospital Department of Medicine to ANM.
- Β© 2018
210-7222222
Υπουργείο Υγείας - Οδηγία Υ1/3239/2000
