Ο B.A. εξομολογείται...

Boy Πριν από περίπου ένα μήνα έμαθα ότι είμαι οροθετικός.
Και όχι μόνο εγώ αλλά και η γυναίκα μου.

Υποθέτω ότι εγώ της μετέδωσα τον ιό.
Η γυναίκα μου είναι έγκυος. Περιμένουμε το πρώτο μας παιδί. Ελπίζω να μην έχει κολλήσει και αυτό τον ιό.

Στο μυαλό μου έχω μπερδεμένες σκέψεις. Δεν ξέρω τι να κάνω. Δεν ξέρω πως να το αντιμετωπίσω.
Φοβάμαι για όλους μας.
Θέλω να ζησουμε.
Θέλω να ζήσουμε μια φυσιολογική ζωή.
Ειλικρινά φοβάμαι πολύ.

Δεν νιώθω θυμό ή οργή.
Μόνο φοβάμαι!

B.Α.




... 'Aλλες ιστορίες ...

21/2/2017
News : Το ΚΕΕΛΠΝΟ σε Χίο και Μυτιλήνη για τη διαχείριση περιστατικών HIV στις προσφυγικές δομές. Ο πρόεδρος του ΚΕΕΛΠΝΟ, αναπληρωτής καθηγητής Θεόφιλος Ρόζενμπεργκ, ανακοινώσε την αποστολή διεπιστημονικού κλιμακίου του Οργανισμού εντός των επόμενων ημερών, στα δύο νησιά. Προς το σκοπό της προάσπισης της δημόσιας υγείας, το κλιμάκιο του ΚΕΕΛΠΝΟ θα επικεντρωθεί στην ενημέρωση των επαγγελματιών υγείας για την ορθή διαχείριση των περιστατικών HIV στον προσφυγικό/μεταναστευτικό πληθυσμό και στην αγωγή υγείας στην κοινότητα και την ψυχοκοινωνική στήριξη.
14/2/2017
News : Θεσσαλονίκη: Δωρεάν τεστ για HIV, ηπατίτιδες Β και C σήμερα. Η ΜΚΟ PRAKSIS και το Κέντρο Ζωής γιορτάζουν τη μέρα του Αγίου Βαλεντίνου στην Καμάρα με δράσεις ενημέρωσης, πρόληψης και εξέτασης. Στελέχη της PRAKSIS με την Κινητή Μονάδα Εξέτασης θα βρεθούν την Τρίτη 14 Φεβρουαρίου, από τις 18.00 έως και τις 22.00 στην Καμάρα παρέχοντας τη δυνατότητα να ενημερώσουν τους πολίτες για τον HIV και για τις Ηπατίτιδες, ενθαρρύνοντας τους παράλληλα να εξεταστούν δωρεάν, ανώνυμα και γρήγορα. Η εξέταση αφορά όλα τα άτομα που έχουν ενεργή σεξουαλική ζωή.
9/2/2017
News : Το ABX464 είναι ένα μοναδικό αντι-ιικό σύμπλεγμα μικρών μορίων που στοχεύουν την RNA βιογένεση. Αυτό το μόριο είναι το πρώτο στην κατηγορία του με μοναδικές ιδιότητες και τρόπο δράσης. Συγκεκριμένα, αναστέλλει την πρωτεΐνη REV HIV, η οποία είναι κρίσιμη για την αντιγραφή του HIV. Το ABX464 αναστέλλει in vitro και in vivo την αντιγραφή του ιού και προκαλεί μακρόχρονη μείωση του ιικού φορτίου μετά τη διακοπή της θεραπείας σε ένα προκλινικό μοντέλο του HIV. Συνεπώς, το ABX464 μπορεί να είναι η πρώτη ανάπτυξη μιας λειτουργικής θεραπείας για το HIV

Το video της ημέρας

Video

RUINS - Cronicle of an HIV witch-hunt

Δημοσιεύθηκε στις 2013-12-01

Οι φωτογραφίες και τα προσωπικά δεδομένα συνανθρώπων μας θετικών στον ιό HIV, όλες τους γυναίκες, άρχισαν να παρελαύνουν στις βραδινές ειδήσεις και τα πρωϊνάδικα. Σύμφωνα με τις αρχικές πληροφορίες, και οι 31 γυναίκες ήταν ιερόδουλες που συνελήφθησαν σε μια μαζική επιχείρηση σκούπα της αστυνομίας, η οποία δημοσίευσε τις φωτογραφίες τους μετά από εισαγγελική εντολή. Γιατροί από το Κέντρο Ελέγχου και Πρόληψης Νοσημάτων δήλωναν σε συνεντεύξεις ότι θα ακολουθούσαν και άλλοι «έλεγχοι». Υπουργοί, αστυνομικοί και εκπρόσωποι του ιατρικού χώρου στήριζαν δημόσια την επιχείρηση ως μια επείγουσα κίνηση, απαραίτητη για την προστασία Ελλήνων αντρών και των οικογενειών τους.




Synergistic Impact of Training Followed By on-Site Support on Hiv Clinical Practice: A Mixed Design Study in Uganda with Pre/Post and Cluster Randomized Trial Components

Tue, 16 Jan 2018 00:00:00 GMT-06:00 - Burnett, Sarah; Mubiru, Norbert; Imani, Peace; Mbonye, Martin K.; Fisher, Leigh; Colebunders, Robert; Manabe, Yukari C.; Weaver, Marcia R. Abstract:
Εισαγωγή:Task-shifting can expand antiretroviral therapy access, but little is known about effective approaches to improve clinical practice among mid-level practitioners’ (MLP) such as clinical officers, nurses, and midwives. The Integrated Infectious Diseases Capacity-Building Evaluation compared training alone to training combined with on-site support (OSS).
Μέθοδοι:Two MLP each from 36 health facilities attended the five-week Integrated Management of Infectious Disease training. Following training, 18 facilities randomly assigned to arm A received OSS for nine months, while 18 arm B facilities did not. Clinical faculty assessed MLP HIV clinical practice on six tasks: history taking, physical examination, laboratory investigations, diagnosis, treatment, and patient education. We analyzed the effect of training alone and training combined with OSS as the pre/post change within each arm. We analyzed the incremental effect of OSS with a difference-in-difference analysis that compared changes between arms.
Αποτελέσματα:Training alone and training combined with OSS significantly improved clinical practice in patient history taking (13% and 24% increase, respectively), physical examination (54% and 71%), laboratory investigations (32% and 20%) and diagnosis (31% and 51%). Combined training and OSS also improved patient education significantly (72% increase). Effect sizes for training combined with OSS were larger than for training alone except for laboratory investigations, and the effects were robust in sensitivity analyses. The incremental effect of OSS on diagnosis was significant (adjusted relative relative risk=1.23; 95% CI=1.00-1.50).
Συμπέρασμα:Combined training and OSS improved MLP HIV clinical practice over training alone and can contribute to continued expansion of access to antiretroviral therapy.This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal.
Εισαγωγή: Task-shifting can expand antiretroviral therapy access, but little is known about effective approaches to improve clinical practice among mid-level practitioners’ (MLP) such as clinical officers, nurses, and midwives. The Integrated Infectious Diseases Capacity-Building Evaluation compared training alone to training combined with on-site support (OSS).
Μέθοδοι: Two MLP each from 36 health facilities attended the five-week Integrated Management of Infectious Disease training. Following training, 18 facilities randomly assigned to arm A received OSS for nine months, while 18 arm B facilities did not. Clinical faculty assessed MLP HIV clinical practice on six tasks: history taking, physical examination, laboratory investigations, diagnosis, treatment, and patient education. We analyzed the effect of training alone and training combined with OSS as the pre/post change within each arm. We analyzed the incremental effect of OSS with a difference-in-difference analysis that compared changes between arms.
Αποτελέσματα: Training alone and training combined with OSS significantly improved clinical practice in patient history taking (13% and 24% increase, respectively), physical examination (54% and 71%), laboratory investigations (32% and 20%) and diagnosis (31% and 51%). Combined training and OSS also improved patient education significantly (72% increase). Effect sizes for training combined with OSS were larger than for training alone except for laboratory investigations, and the effects were robust in sensitivity analyses. The incremental effect of OSS on diagnosis was significant (adjusted relative relative risk=1.23; 95% CI=1.00-1.50).
Συμπέρασμα: Combined training and OSS improved MLP HIV clinical practice over training alone and can contribute to continued expansion of access to antiretroviral therapy. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. Corresponding Author: Sarah Burnett, MPH, MPA, PATH, Washington, DC UNITED STATES The authors report no conflicts of interest related to this work. Authors’ contributions: MKM and MRW conceived and designed the experiments. SMB, LF, PI, and MRW analyzed the data. SMB, NM, and MRW wrote the paper. RC and YM reviewed the manuscript to meet submission requirements. All authors reviewed and approved final submission. - Β© 2018

Higher Art Adherence is Associated with Lower Systemic Inflammation in Treatment-NaΓ―ve Ugandans Who Achieve Virologic Suppression

Tue, 16 Jan 2018 00:00:00 GMT-06:00 - CASTILLO-MANCILLA, Jose R.; MORROW, Mary; BOUM, Yap; BYAKWAGA, Helen; HABERER, Jessica E.; MARTIN, Jeffrey N.; BANGSBERG, David; MAWHINNEY, Samantha; MUSINGUZI, Nicholas; HUANG, Yong; TRACY, Russell P.; BURDO, Tricia H.; WILLIAMS, Kenneth; MUZOORA, Conrad; HUNT, Peter W.; SIEDNER, Mark J. Abstract
Εισαγωγή:Residual systemic inflammation persists despite suppressive antiretroviral therapy (ART) and is associated with non-AIDS clinical outcomes. We aimed to evaluate the association between ART adherence and inflammation in Ugandans living with HIV who were predominantly receiving nevirapine-based ART with a thymidine analog backbone and were virologically suppressed by conventional assays.
Μέθοδοι:Plasma concentrations of interleukin-6 (IL-6), D-dimer, soluble (s)CD14, sCD163, the kynurenine/tryptophan (K/T) ratio, in addition to CD8+ T-cell activation, were measured at baseline and 6 months after ART initiation in treatment-naΓ―ve adults who achieved an undetectable plasma HIV RNA (<400 copies/mL) at their 6-month visit. Adherence was measured through medication event monitoring system (MEMS) and calculated as the ratio of observed/prescribed device openings per participant. We fit adjusted linear regression models to estimate the association between ART adherence and the log-transformed plasma concentrations of inflammatory biomarkers.
Αποτελέσματα:We evaluated 282 participants, median age 35 years, 70% women. The median (IQR) adherence was 93 (84, 98) %. In the adjusted analyses, for every 10% increase in average ART adherence, we found a 15% (P<0.0001, 95% CI -21.0, -7.9), 11% (P=0.017, -18.3, -2.0) and 3% (P=0.028, -5.0, -0.3) decrease in IL-6, D-dimer and sCD14, respectively.
Συμπεράσματα:Higher ART adherence was associated with lower levels of biomarkers of inflammation, immune activation and coagulopathy among Ugandans living with HIV who achieved viral suppression shortly after ART initiation. This suggests that ART adherence could have biological consequences beyond viral suppression. Whether ART adherence optimization in virologically-suppressed individuals could reduce residual inflammation remains unknown.This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal.
Εισαγωγή: Residual systemic inflammation persists despite suppressive antiretroviral therapy (ART) and is associated with non-AIDS clinical outcomes. We aimed to evaluate the association between ART adherence and inflammation in Ugandans living with HIV who were predominantly receiving nevirapine-based ART with a thymidine analog backbone and were virologically suppressed by conventional assays.
Μέθοδοι: Plasma concentrations of interleukin-6 (IL-6), D-dimer, soluble (s)CD14, sCD163, the kynurenine/tryptophan (K/T) ratio, in addition to CD8+ T-cell activation, were measured at baseline and 6 months after ART initiation in treatment-naΓ―ve adults who achieved an undetectable plasma HIV RNA (<400 copies/mL) at their 6-month visit. Adherence was measured through medication event monitoring system (MEMS) and calculated as the ratio of observed/prescribed device openings per participant. We fit adjusted linear regression models to estimate the association between ART adherence and the log-transformed plasma concentrations of inflammatory biomarkers.
Αποτελέσματα: We evaluated 282 participants, median age 35 years, 70% women. The median (IQR) adherence was 93 (84, 98) %. In the adjusted analyses, for every 10% increase in average ART adherence, we found a 15% (P<0.0001, 95% CI -21.0, -7.9), 11% (P=0.017, -18.3, -2.0) and 3% (P=0.028, -5.0, -0.3) decrease in IL-6, D-dimer and sCD14, respectively.
Συμπεράσματα: Higher ART adherence was associated with lower levels of biomarkers of inflammation, immune activation and coagulopathy among Ugandans living with HIV who achieved viral suppression shortly after ART initiation. This suggests that ART adherence could have biological consequences beyond viral suppression. Whether ART adherence optimization in virologically-suppressed individuals could reduce residual inflammation remains unknown. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. Corresponding Author: Jose R. Castillo-Mancilla, MD. Division of Infectious Diseases, Department of Medicine, University of Colorado Anschutz Medical Campus. 12700 E 19th Ave., B168, Aurora, CO 80045, (o) 303 724 4934, (f) 303 724 4926 jose.castillo-mancilla@ucdenver.edu The authors report no conflicts of interest related to this work. Presented at: Conference on Retroviruses and Opportunistic Infections, February 13–16, 2017, Seattle, Washington. Abstract Number: 675 Sources of Funding: the Uganda AIDS Rural Treatment Outcomes Study is funded by U.S. National Institutes of Health (NIH) R01 MH54907, P30 AI27763, UM1 CA181255 and the Sullivan Family Foundation. J.C.M. was supported by NIH/NIAID grants K23 AI104315 and R21 AI124859. M.J.S. was supported by the NIH (K23 MH099916) and the Harvard Center for AIDS Research (P30 AI 060354). This study was also supported by NIH grants R56 AI100765, R21 AI078774, T32 AA007240 and P01 AI076174 and the Doris Duke Charitable Foundation (Clinical Scientist Development Award #2008047). - Β© 2018

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